DENVER (AP) -- Peyton Manning's receivers played keep-away with his milestone memento and the NFL's new leader in career touchdown passes toyed with the San Francisco 49ers in the Denver Broncos' emphatic 42-17 victory Sunday night.
Manning went into the showdown two TDs shy of Brett Favre's record of 508 and threw four touchdown passes, giving him 510.
He surpassed Favre's mark with an 8-yard strike to Demaryius Thomas late in the second quarter. As he went to retrieve the football, his teammates decided to have some fun.
Thomas tossed the historic ball over Manning and to Emmanuel Sanders, who then lobbed it to Wes Welker. From there, Welker dished it back to Sanders, who then flipped it to Julius Thomas - all of Manning's favorite targets getting into the act.
Finally, Manning got the ball along with congratulations from his teammates and coaches.
JAGUARS 24, BROWNS 6
JACKSONVILLE, Fla. (AP) - The Jacksonville Jaguars are winless no more.
Denard Robinson ran for a career-high 127 yards and a touchdown, Jacksonville's defense came up big in the red zone, and the Jaguars snapped a nine-game losing streak.
Jacksonville (1-6) won for the first time since beating Houston on Dec. 15, 2013.
Blake Bortles connected with fellow rookie Allen Robinson for a 31-yard score and the game's first touchdown. It was really all the Jaguars needed on a day in which coach Gus Bradley's defense delivered time and time again.
The Browns (3-3) settled for field goals in two trips inside the 20-yard line and failed to convert on fourth-and-1 at the 24.
Cleveland, which entered the game with the league's third-best rushing attack, was held in check most of the day. The Browns ran 30 times for 69 yards, including 36 by Ben Tate.
RAMS 28, SEAHAWKS 26
ST. LOUIS (AP) - Punter Johnny Hekker's pass from the St. Louis 18 caught the Seattle Seahawks by surprise for the last of three big plays by Rams special teams.
Stedman Bailey had a 90-yard touchdown on a trick return that fooled the Seahawks into thinking another player was going to catch the punt. Benny Cunningham's 75-yard kickoff return set up an early touchdown for the Rams (2-4).
Russell Wilson rushed for 106 yards on seven carries and also passed for two touchdowns while going 23 for 36 for 313 yards.
The Seahawks (3-3) dominated statistically, outgaining the Rams 463-272. Doug Baldwin's' 9-yard reception cut the deficit to two with 3:18 to go, but the Rams were able to run out the clock after Hekker's completion to Cunningham.
COWBOYS 31, GIANTS 21
ARLINGTON, Texas (AP) - Tony Romo threw three touchdown passes, and DeMarco Murray broke Jim Brown's 56-year-old NFL record with his seventh straight 100-yard rushing game to start a season.
The Cowboys (6-1) won their sixth straight.
Romo had a fourth scoring pass overturned on replay. Instead, Murray wound up with his seventh TD rushing on a 1-yard plunge.
Murray finished with 128 yards rushing to pass Brown, who hit the century mark in the first six games of the 1958 season for Cleveland.
The Cowboys are off to their best start since they went 13-3 in 2007 and were the top seed in the NFC before losing to New York in their first playoff game.
Eli Manning had three touchdown passes for the Giants (3-4), who have lost at the NFC East's top two teams in consecutive weeks.
CHIEFS 23, CHARGERS 20
SAN DIEGO (AP) - Cairo Santos kicked a 48-yard field goal field goal with 21 seconds left and the Chiefs snapped the Chargers' five-game winning streak.
The Chiefs moved into field goal range thanks to Alex Smith, who completed three straight passes for 43 yards, including a 29-yarder to Dwayne Bowe. Smith was playing on the same field where he led Helix High to consecutive San Diego Section championships.
Coming off their bye, the Chiefs (3-3) made the AFC West a three-team race, pulling within 1 1/2 games of San Diego (5-2). The Broncos (5-1) lead the division.
The Chiefs' Andy Reid is 14-2 after a bye week, the most victories for any coach.
The Chargers flunked their sternest test in a month and lost for the first time since a defeat at Arizona in the season opener.
CARDINALS 24, RAIDERS 13
OAKLAND, Calif. (AP) - Carson Palmer threw two touchdown passes in his return to Oakland to send the Raiders to their 12th straight loss.
Stepfan Taylor caught one touchdown pass and ran for another, and Andre Ellington gained 160 yards from scrimmage for the Cardinals (5-1), who are off to their best start since 1976.
Darren McFadden ran for a touchdown for the Raiders (0-6), off to their worst start to a season since losing their first 13 games in 1962 - the year before late owner Al Davis joined the franchise.
LIONS 24, SAINTS 23
DETROIT (AP) - Matthew Stafford threw two touchdown passes in the final 3:38, including the winner to Corey Fuller with 1:48 remaining.
The Saints (2-4) were in control late in the fourth quarter when Stafford found Golden Tate for a 73-yard catch-and-run that made it 23-17. Then Drew Brees was intercepted on third down by Glover Quin, whose 23-yard return gave the Lions (5-2) the ball at the New Orleans 14.
Detroit caught a break when Rafael Bush was called for pass interference on fourth down. Stafford eventually connected with Fuller in the back of the end zone for a 5-yard touchdown and the win.
The Saints committed 12 penalties for 134 yards.
COLTS 27, BENGALS 0
INDIANAPOLIS (AP) - Andrew Luck threw two touchdown passes and the Colts' defense dominated Cincinnati. Luck was 27 of 42 for 344 yards as Indianapolis (5-2) won its fifth straight. It was Indy's first shutout since December 2008 and the 500th victory in franchise history.
Cincinnati (3-2-1), which hasn't won since starting 3-0, endured its first shutout since December 2009 and had a franchise record tying 11 punts Sunday. Andy Dalton was 18 of 38 for 126 yards.
Indy churned out 506 yards, struck early and pulled away late.
Bradshaw's 1-yard TD run made it 10-0 in the second quarter and Luck threw two second-half TD passes to make it 24-0.
Colts linebacker Erik Walden was ejected in the first half for making contact with umpire Bruce Stritesky.
PACKERS 38, PANTHERS 17
GREEN BAY, Wis. (AP) - Aaron Rodgers threw for 255 yards and three touchdowns, and Randall Cobb torched the Carolina secondary for 121 yards on receptions.
Sure-tackling Green Bay (5-2) limited quarterback Cam Newton in the first half. The Packers scored touchdowns on their first three series and led 28-3 at halftime, eliminating the threat of the Panthers' running game.
Newton, who had a career-high 17 carries last week, had 41 yards rushing on seven attempts. He passed for 205 yards for Carolina (3-3-1).
The Packers never looked back after Rodgers connected with Jordy Nelson for a 59-yard touchdown pass on the opening drive in winning their fourth straight. Eddie Lacy and James Starks each added TDs rushing in the first half.
RAVENS 29, FALCONS 7
BALTIMORE (AP) - Elvis Dumervil and Pernell McPhee each had two sacks, part of a dominant defensive performance that carried the Ravens.
Baltimore (5-2) led 17-0 at halftime and coasted to its second straight blowout win. The Ravens beat Tampa Bay 48-17 last week.
The Falcons (2-5) averted their first shutout loss since December 2004 when Matt Ryan connected with Roddy White for a 4-yard touchdown with 7:12 remaining. It was Atlanta's first fourth-quarter score in five games.
Terrell Suggs sacked Ryan for a safety and Joe Flacco threw a 39-yard touchdown pass to Torrey Smith on a fourth-and-9 to seal Baltimore's fourth win in five games.
The Ravens allowed only four first downs in the pivotal first half and finished with five sacks in dealing the Falcons their fourth straight defeat.
DOLPHINS 27, BEARS 14
CHICAGO (AP) - Ryan Tannehill threw for 277 yards and two touchdowns in an efficient performance. Tannehill connected on his first 14 passes and was 25 of 32 overall, helping Miami bounce back from a brutal 27-24 loss to Green Bay.
Lamar Miller also had a 2-yard touchdown run for the Dolphins (3-3), who had lost three of four since an opening victory over New England.
The Bears (3-4) remained winless in three home games this season and have dropped five of their last seven at Soldier Field. Matt Forte scored two touchdowns and Jeremiah Ratliff finished with a career-best 3 1/2 sacks.
REDSKINS 19, TITANS 17
LANDOVER, Md. (AP) - Kai Forbath kicked a 22-yard field goal on the last play of the game, and Colt McCoy stepped in after Kirk Cousins was benched at halftime to lead the Redskins.
McCoy completed 11 of 12 passes for 128 yards and a touchdown in his first meaningful role in a win since Nov. 20, 2011. Back then, he led the Browns to a 14-10 victory over the Jaguars.
The Redskins (2-5) snapped a four-game losing streak. The Titans fell to 2-5.
McCoy's first pass was a career-long 70-yard touchdown to Pierre Garcon after the Redskins trailed 10-6 at halftime.
Charlie Whitehurst was 17 for 26 for 160 yards with two touchdowns and one interception for the Titans.
BILLS 17, VIKINGS 16
ORCHARD PARK, N.Y. (AP) - Kyle Orton hit Sammy Watkins on a 2-yard touchdown pass with 1 second remaining. The touchdown capped a 15-play, 80-yard drive which Orton extended by converting a fourth-and-20 and a third-and-12. Orton set up the decisive score with a 28-yard pass to Chris Hogan at the Vikings 2.
Orton overcame an interception, a lost fumble and six sacks to finish 31 of 43 for 283 yards and two touchdowns - both to Watkins.
It was Orton's second last-second victory in three starts for Buffalo (4-3), which overcame injuries to running backs Fred Jackson and C.J. Spiller.
The Vikings' defense forced four turnovers. Teddy Bridgewater went 15 of 26 for 157 yards with a touchdown and two interceptions as Minnesota (2-5) lost its third in a row.