Jan 21, 10:13 PM EST

Karlsson scores 2 goals, Senators beat Maple Leafs 4-3

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OTTAWA, Ontario (AP) -- Erik Karlsson scored two goals to lead the Ottawa Senators to a 4-3 win over the struggling Toronto Maple Leafs on Wednesday night.

Mike Hoffman and Mika Zibanejad also scored for the Senators (19-18-9), and Craig Anderson stopped 37 shots.

David Clarkson, Nazem Kadri and James van Riemsdyk had goals for the Maple Leafs (22-23-3), who head into the NHL All-Star break on a six-game skid.

James Reimer made 22 saves and lost for just the second time at Ottawa (8-2).

Toronto made things interesting when Kadri's power-play goal at 2:36 of the third period cut the Maple Leafs' deficit to 3-2. Kadri took a pass from Morgan Rielly and beat a screened Anderson.

The Maple Leafs pressed for the tying goal, but they were unable to create any real solid scoring chances.

With 4:40 remaining, Karlsson scored his second of the night to make it 4-2. Milan Michalek grabbed the puck behind the net and found Karlsson just inside the blue line for a shot that beat Reimer to the glove side.

Van Riemsdyk scored with 1:23 left, but Toronto was unable to complete the comeback.

Trailing 3-0 after 20 minutes, the Maple Leafs had a better second period but were only able to beat Anderson once. Clarkson, with his second goal in 20 games, got the Leafs on the board 13:55 into the middle period.

The Senators nearly regained the three-goal lead late in the frame, but Reimer stopped a 2-on-1 to keep Toronto within reach.

The Maple Leafs had an opportunity to score in the opening minutes of the game as Phil Kessel had a breakaway, but his shot went wide of the net. Less than a minute later, Mark Stone - who extended his point streak to seven games with an assist - fed Hoffman at center ice for a shot that beat Reimer under the crossbar.

Midway through the period, Karlsson capped off a great give-and-go with Hoffman for his 10th goal of the season.

The Senators capped the period scoring on a delayed penalty call when Bobby Ryan found Zibanejad alone.

NOTES: D Chris Phillips, C Colin Greening and C David Legwand were healthy scratches. C Zack Smith (wrist) and D Mark Borowiecki (leg) remained sidelined for the Senators. ... Toronto D Stephane Robidas and D Korbinian Holzer were healthy scratches. Maple Leafs center Leo Komarov was out due to a lower-body injury.

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