MOORE, Okla. (AP) -- Tornado warnings have been issued across much of the Midwest, stretching from Oklahoma to Illinois, following a second deadly twister in as many days in the Oklahoma City area.

The National Weather Service issued tornado warnings Monday evening for several counties in southeastern Oklahoma and north and western Arkansas, along with parts of southern and central Missouri and a small slice of western Illinois.

The warnings are in effect into early morning Tuesday, with multiple tornadoes possible.

The warnings were issued after a massive tornado tore through parts of suburban Oklahoma City, flattening entire neighborhoods with winds up to 200 mph and landing a direct blow on an elementary school in Moore.

The Oklahoma Medical Examiner's Office says dozens were killed, with the death toll expected to rise.