ORCHARD PARK, N.Y. (AP) — Buffalo Bills coach Sean McDermott on Friday ruled out starting linebacker Terrel Bernard, receiver Curtis Samuel and backup rookie defensive tackle DeWayne Carter from playing at Seattle this weekend.

Bernard is sidelined with an ankle injury sustained in a 34-10 win over Tennessee last weekend, and comes after Buffalo's defensive signal-caller missed two games with a pectoral injury sustained in Week 2. Bernard was in on eight tackles and recovered a fumble before he was hurt.

The Bills placed Carter on injured reserve, meaning he’ll miss a minimum of four games. McDermott said Carter requires surgery to repair a wrist injury. He’s eligible to return for Buffalo’s game against San Francisco on Dec. 1, following the Bills bye weekend off.

The rookie third-round pick's playing time has gradually increased, and is coming off a game in which he made a game-turning play. Carter stuffed running back Tony Pollard for a 2-yard loss on fourth down on the Titans' second-half opening drive to set up Buffalo scoring the go-ahead points on its next possession.

Samuel is out indefinitely with a pectoral injury sustained on Sunday. His injury leaves the AFC East-leading Bills (5-2) with four receivers — including Amari Cooper, acquired in a trade with Cleveland last week — in traveling to play the NFC West-leading Seahawks (4-3) on Sunday.

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