PARIS (AP) — Novak Djokovic pulled out of the the French Open with an injured knee on Tuesday, an abrupt end to his title defense and to his current stay at No. 1 in the rankings.

“I am really sad to announce that I have to withdraw from #rolandgarros," Djokovic posted on social media. "I played with my heart and gave my all in yesterday’s match and unfortunately, due to a medial meniscus tear in my right knee, my team and I had to make a tough decision after careful consideration and consultation.”

The tournament said the extent of the injury was found during an MRI exam Tuesday. Djokovic was hurt during a fourth-round victory against No. 23 Francisco Cerundolo on Monday that lasted five sets spread across more than 4 1/2 hours. It was his second consecutive five-setter, with his total time on court across the two exceeding 9 hours.

The 24-time Grand Slam champion was supposed to face No. 7 seed Casper Ruud, the runner-up each of the past two years at Roland Garros, in the quarterfinals on Wednesday. Instead, Ruud gets a walkover into the semifinals, where he will face No. 4 Alexander Zverev or No. 11 Alex de Minaur.

With Djokovic, the owner of three French Open titles, gone from the bracket, and Rafael Nadal — owner of a record 14 — eliminated in the first round, someone will be holding the French Open men's trophy for the first time on Sunday.

The group of remaining contenders includes No. 2 seed Jannik Sinner, a 22-year-old Italian who defeated No. 10 Grigor Dimitrov 6-2, 6-4, 7-6 (3) on Tuesday to get to the semifinals and now is assured of replacing Djokovic atop the ATP rankings next week.

Sinner won the Australian Open in January and becomes the first man from his country to reach No. 1.

His match against Dimitrov was in progress when news of Djokovic's withdrawal spread. So Sinner had no idea until he was asked about it during an on-court interview after his win.

“Seeing Novak (injured) is, for everyone, disappointing,” Sinner said, “so I wish him a speedy recovery.”

And as for his newfound status?

“It means a lot to me, for sure,” said Sinner, who will renew his exciting rivalry with No. 3 Carlos Alcaraz in Friday's semifinals.

Alcaraz reached the final four in Paris for the second year in a row — he cramped up and lost to Djokovic in 2023 — by defeating No. 9 Stefanos Tsitsipas 6-3, 7-6 (3), 6-4 on Tuesday night.

Sinner and Alcaraz have played eight times, splitting them 4-4. They have played twice at majors, splitting those 1-1.

“Well, it's a really difficult challenge. I'm not going to lie. Right now, he's the best player in the world — or the player who is playing the best tennis right now,” Alcaraz said. “It is the match that everybody wants to watch.”

Amid a season in which Djokovic is only 18-6 and has not reached a final at any tournament, let alone won one, he needed to get back to the title match at the French Open to continue to add to his record for most weeks at No. 1.

For years and years, Djokovic, Nadal and Roger Federer ruled men's tennis as the so-called Big Three, accumulating a total of 66 major championships among them. But Federer, now 42, is retired, and Nadal, who turned 38 on Monday, is trying to figure out how much longer he can compete after missing most of the past 1 1/2 seasons with injuries.

No one knows yet how long Djokovic, 37, will be sidelined or what, if any, effect this might have on his future.

Wimbledon, where has won seven titles, starts July 1, and the tennis competition at the Paris Olympics starts at Roland Garros on July 27.

“I saw that he was obviously physically struggling (Monday), and I honestly thought ... he was on the verge of losing,” said U.S. Open champion Coco Gauff, who made her way into the women's semifinals with a three-set win over Ons Jabeur and will play No. 1 Iga Swiatek on Thursday.

Seeing Djokovic pull out the win against Cerundolo, Gauff said, made her think “that he would win the title.”

Djokovic's knee had been bothering him for a couple of weeks before he arrived in Paris for the French Open — something he kept to himself until after the win against Cerundolo. Early in the second set Monday, Djokovic tweaked his knee and took a medical timeout. A trainer worked on the joint then and during subsequent changeovers, and Djokovic took what he said a tournament doctor told him was the maximum dose of pills allowed to dull the pain and reduce any inflammation.

“I don’t know what will happen tomorrow — or, after tomorrow, if I’ll be able to step out on the court and play,” Djokovic said Monday evening.

Djokovic trailed by two sets to one, and was down a break at 4-2 in the fourth, against Cerundolo before raising his level of play once the medication kicked in.

“I was,” Djokovic said afterward, “maybe three or four points away from losing this match.”

Yes, he stuck it out, and, yes, he came back to win — it was his 370th victory in Grand Slam play, breaking a tie with Federer for the most in tennis history — but it was costly. And Djokovic said Monday he thought it could have been prevented if the clay inside Court Philippe Chatrier had been cared for better.

Both in that match — and during his 4 1/2-hour victory in the third round, which ended after 3 a.m. Sunday — Djokovic tried to get the chair umpires to have the court swept more frequently to improve traction.

“I mean, today I injured myself. Yes, I survived. I won the match. Great. But will I be able to play next one?” he said, tapping his palms on a table for emphasis.

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