ORCHARD PARK, N.Y. (AP) — Titans starting quarterback Will Levis is out due to an injury to his throwing shoulder, leading to backup Mason Rudolph getting the start against the Buffalo Bills on Sunday.

Levis has been bothered by an AC joint injury to his right shoulder and was listed as questionable to play after being limited in two of three practice sessions this week. The second-year player is coming off an outing in which he finished with a career-worst 95 yards passing in a 20-17 loss to Indianapolis last week.

It’s unclear whether he aggravated the injury in practice this week, and how long he might be sidelined.

Levis has struggled in losing all four games he’s started and finished this season, while learning a new offense under first-year coach Brian Callahan. Levis has five touchdowns passing and an NFL-leading seven interceptions to go along with three lost fumbles.

Rudolph, an offseason free agent addition, is making his first start and second appearance with Tennessee after he took over for an injured Levis in a 31-12 win at Miami on Sept. 30. The 29-year-old player has an 8-4-1 career record after spending his first six seasons in Pittsburgh.

Trevor Siemian was elevated off the Titans practice squad to fill the backup role.

The Titans (1-4) are also missing Treylon Burks after the receiver hurt his knee in practice and placed on injured reserve on Saturday, and starting cornerback L'Jarius Sneed (quadriceps).

As expected for Buffalo (4-2), receiver Amari Cooper is active and preparing to make his Bills' debut after being acquired in a trade with Cleveland on Tuesday.

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